Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a common hormonal, metabolic and reproductive disorder characterized by androgen excess, ovulatory dysfunction and polycystic ovaries. The phenotypic presentation might differ between referral and unselected populations and varies within an individual over time and between individuals of different ethnic and geographic regions. Women with PCOS have increased prevalence of prediabetes and diabetes and have multiple risk factors for cardiometa...

Obesity and type 2 diabetes are common and complex traits that are closely related and the term ‘diabesity’ is being used for the twin global epidemic of these two disorders. PCOS is another common and complex disorder characterized by androgen excess, oligo-anovulation and polycystic ovaries on ultrasound. PCOS is linked with both obesity and type 2 diabetes. Although obesity and type 2 diabetes are not universally observed in PCOS, many women with PCOS are obese an...

Hirsutism, defined as excessive male-pattern terminal hair growth in females, affects about 5–10% of the women of reproductive age depending on the population studied and the method used to determine its presence. Hirsutism is the primary clinical diagnostic criterion of hyperandrogenism. Hyperandrogenism can result from increased androgen production and/or increased sensitivity of hair follicles to androgens. The presence of hirsutism in women can lead to significant psy...

Background: Conversion rates of the presentations into publications could be a measure of the scientific Impact of a conference. The aim of the current study was to determine the publication rates of abstracts presented at the 16th European Congress of Endocrinology (ECE 2014) and the factors affecting these rates by using computer algorithms specially coded for this analysis.Methods: All presentations of the ECE 2014 were collected with the web scraping...

Background and Aim: Polycystic ovary syndrome (PCOS) is associated with compositional and functional alterations in gut microbiota. The cytokine interleukin-22 (IL-22) is produced by both innate and adaptive immune cells and closely linked to gut immunity. IL-22 is tightly controlled by its binding protein (IL-22BP), which serves as an antagonist of IL-22 signaling. Preliminary animal studies and limited human data in Asian populations suggest lower circulating levels of IL-22...

Background: The symptoms typically associated with polycystic ovary syndrome (PCOS) such as acne, hirsutism, irregular menses, amenorrhoea, obesity and infertility are a major source of psychological morbidity and can negatively affect quality of life (QOL). Limited data are available regarding effects of different treatment modalities on emotional distress of women with PCOS.Objective: To determine potential impact of treatment on health-related quality...

Developments of the cancer immunology have increased the frequency of use of targeted therapies and immunomodulatory therapies. Although these treatments are effective on cancer cells, they also have toxicity on the thyroid gland. We aimed to evaluate the tyrosine kinase inhibitors(TKI) and immunotherapies-induced thyroid disorders, their relationship on disease prognosis and baseline serum thyroid stimulating hormone (TSH) levels effect on the development of thyroid dysfuncti...

Background: Proton-density fat fraction (PDFF), derived from chemical shift encoding-based water-fat magnetic resonance imaging, has emerged as an important surrogate method for calculation of fat composition in a number of tissues including liver, vertebrae and muscles. This study aims to determine whether fat composition of these tissues, as well as visceral and subcutaneous adiposity differ between women with PCOS and healthy controls.Methods: 17 lean...

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...

Context: Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder. Emerging animal and human data point out to various changes in microbiota that could be linked with the syndrome. However, the effects of therapeutic approaches on gut microbial composition in women with PCOS remain unknown.Objective: We aimed to assess whether gut microbial composition is altered in overweight/obese women with PCOS and to determine potential impact of ...